Membrane protein function is often responsive to signals such as circulating hormones or local mediators. For every stimulus or variable, unique PPIs likely occur.
Proteins might interact for a long time to form a functional complex, or briefly with another protein to modify it. Dynamic regulation of membrane proteins is essential and often responsible for eliciting a quick response to any given stimulus in order to maintain specific cell function. Biochemical and cellular function can be changed simply by altering the protein location in the cell. In RA2 we will use an array of advanced live cell imaging techniques to determine the dynamics and location of complex formation.